Seminar announcement 13th May 2015
Gene expression in hydrogels
Commercial biological assays are usually performed in dilute solution in bulk. As a result, they do not reflect key properties of a cell: cytosol crowding and spatial organization on microscopic length scales. Therefore, insights on diffusion processes as well as reaction kinetics in vivo remain vague. We employ polymer hydrogels as experimental platform to study biological functions such as gene expression to overcome these limitations. In contrast to the inherent complexity of cells, the hydrogel approach serves as a basis to understand and engineer biochemical reaction pathways by means of macromolecular and colloid chemistry.
Dr. Julian Thiele